药品信息:
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Mirapexin - Indications: parkinsonism, restless legs syndrome Monotherapy or in combination w/ levodopa in the treatment of signs & symptoms of idiopathic Parkinson’s disease. Symptomatic treatment of moderate to severe idiopathic Restless Legs Syndrome.
How does it work?
Mirapexin tablets and mirapexin prolonged-release tablets both contain the active ingredient pramipexole, which is a type of medicine called a dopamine agonist. (NB. Pramipexole is also available without a brand name, ie as the generic medicine.)
Pramipexole works by mimicking the activity of a substance in the brain called dopamine.
Dopamine is a substance known as a neurotransmitter. Neurotransmitters are present in the brain and nervous system and are involved in transmitting messages between nerves. These messages allow the normal functioning of the body. The neurotransmitter dopamine is known to be reduced or absent in the brains of people with Parkinson's disease, and this is thought to be the cause of the disease symptoms.
Dopamine normally transmits messages by stimulating specific receptor sites in the brain. Pramipexole works by stimulating these same receptor sites. This produces the same effects as dopamine, and acts as a dopamine substitute. In this way pramipexole helps to restore the dopamine activity in the brain, which helps reduce the symptoms of Parkinson's disease.
Mirapexin tablets and Mirapexin prolonged-release tablets can both be used alone or in conjunction with levodopa to treat Parkinson's disease, and are particularly useful in people for whom levodopa alone is no longer providing adequate control of symptoms.
Mirapexin tablets are also used to treat restless leg syndrome (RLS), though exactly how pramipexole works in this condition is unclear.
Pramipexole can cause a drop in blood pressure when you first start treatment, and this may cause dizziness or fainting. To minimise these side effects the dose is increased slowly, usually over three to four weeks. Follow the instructions given by your doctor or pharmacist.
What is it used for?
Parkinson's disease.
Moderate to severe restless legs syndrome.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
The safety of this medicine in pregnancy has not been established. It should not be used during pregnancy unless considered essential by your doctor, and only if the benefits to the mother outweigh any potential risks to the foetus. Seek medical advice from your doctor.
It is not known if this medicine passes into breast milk, however it is expected that it may suppress the production of breast milk. Consequently this medicine should not be used during breastfeeding. If treatment with this medicine is considered essential, breastfeeding should be stopped. Seek medical advice from your doctor.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
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