药品信息:
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Therapeutic category name
Bicarbonate Ringer's solution
Brand Name
Bikaneito infusion (500mL bag)
Composition
This agent is an injectable solution containing the following ingredients 1 container (500mL) in .
Sodium chloride
2.92g
Potassium chloride
0.15g
Calcium chloride hydrate
0.11g
Magnesium chloride
0.10g
Sodium hydrogen carbonate
1.175g
Sodium citrate hydrate
0.10g
This agent contains citric acid hydrate (pH adjusting agent ) as an additive .
Electrolyte concentration
Na +
130mEq / L
K +
4mEq / L
Mg2 +
2mEq / L
Ca2 +
3mEq / L
Cl-
109mEq / L
HCO3-
28mEq / L
Citrate3-※
4mEq / L
Contraindication
Hypermagnesemia , worsening the hypermagnesemia by the electrolyte composition of [ the drug patients with hypothyroidism , there is a risk of or cause . ]
Effect or efficacy
Supply, the correction of extracellular fluid in reducing the time of interstitial fluid and circulating blood volume , correction of metabolic acidosis.
Careful administration
There is a possibility that [ water , prone to overdose of the electrolyte , symptoms worsen patients with renal insufficiency .
There is a possibility to put a burden on the heart from the fact that increasing the circulating blood volume patients with heart failure , symptoms worsen . ]
Is required to hydration in the patients of this hypertonic dehydration , there is a possibility that the symptoms worse by the administration of this drug , including the electrolyte . ]
There is a possibility that [ the water , you have overload of electrolyte patients with urine volume is reduced by obstructive urinary tract disease , symptoms worsen . ]
Pharmacology
A result of examining the amount excreted as carbon dioxide alkalizing agent using laparotomy invasive rats and normal , was formulated into the extracellular fluid replenisher is metabolized acetate and sodium lactate , formulated in acetate Ringer's solution and lactated Ringer's solution sodium bicarbonate as compared to sodium was formulated into the present agent 5 it is rapidly excreted in the expired air as carbon dioxide) .
In a study using a canine model invasive surgery that made the laparotomy - air exposure , the drug showed the same effects as those of the acetate Ringer's solution and lactated Ringer's solution with respect to the maintenance of blood acid-base balance and circulation dynamics . Level of magnesium in the blood of the group treated with this drug is 6 to maintain the level of pre-dose values) .
Using a rat hemorrhagic shock model , was carried out (100mL/kg/hr administration , 25mL/kg/5min + 75mL/kg/hr administration ) 2 test . In the former , the agent 7 shown the same effect as the acetate Ringer's solution and lactated Ringer's solution for the improvement of blood acid-base balance and circulation dynamics ) . In the latter bolus , blood pressure, with respect to blood bicarbonate ion concentration and excess base , this drug showed rapid improvement as compared with the acetate Ringer's solution . Further , the 8 blood lactate value decreased rapidly than lactate Ringer's solution in this drug ) .
In a study using rat liver resection under hemorrhagic shock model , blood lactate level was increased in the administration of Ringer's lactate , but 9 showed no change in this agent) . |